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Nobuhito Murai Selected Research

indeloxazine

6/2015AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in rat models of nociceptive pain.
6/2014Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
4/2014AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy.
3/2014AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover.

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Nobuhito Murai Research Topics

Disease

9Pain (Aches)
12/2019 - 06/2012
9Hyperalgesia
01/2018 - 12/2008
4Neuralgia (Stump Neuralgia)
11/2017 - 03/2014
4Diabetic Neuropathies (Diabetic Neuropathy)
04/2014 - 12/2008
2Cerebrovascular Disorders (Cerebrovascular Occlusion)
04/2014 - 03/2014
1Myalgia
12/2019
1Fatigue
12/2019
1Fibromyalgia (Fibrositis)
12/2019
1Muscular Atrophy (Muscle Atrophy)
01/2018
1Musculoskeletal Pain
01/2018
1Arthritis (Polyarthritis)
06/2015
1Nociceptive Pain
06/2015
1Hypersensitivity (Allergy)
06/2014
1Body Weight (Weight, Body)
04/2014
1Neoplasms (Cancer)
02/2003
1Neoplasm Metastasis (Metastasis)
02/2003

Drug/Important Bio-Agent (IBA)

7Analgesics (Analgesic Drugs)IBA
12/2019 - 09/2009
6Duloxetine Hydrochloride (Cymbalta)FDA Link
01/2018 - 03/2014
4Pregabalin (Lyrica)FDA Link
01/2018 - 09/2009
4indeloxazineIBA
06/2015 - 03/2014
4Serotonin (5 Hydroxytryptamine)IBA
06/2015 - 03/2014
4Norepinephrine (Noradrenaline)FDA LinkGeneric
06/2015 - 03/2014
4Streptozocin (Streptozotocin)FDA Link
04/2014 - 12/2008
3Amitriptyline (Elavil)FDA LinkGeneric
06/2014 - 09/2009
3Antidepressive Agents (Antidepressants)IBA
06/2014 - 09/2009
3Glucose (Dextrose)FDA LinkGeneric
04/2014 - 12/2008
2Serotonin and Noradrenaline Reuptake InhibitorsIBA
01/2018 - 04/2014
2Diclofenac (SR 38)FDA LinkGeneric
01/2018 - 09/2009
2ProstaglandinsIBA
11/2017 - 06/2014
2ImmunophilinsIBA
06/2012 - 12/2008
2FK1706IBA
06/2012 - 12/2008
2LigandsIBA
06/2012 - 12/2008
1ASP8062IBA
12/2019
1gamma-Aminobutyric Acid (GABA)IBA
12/2019
1Reserpine (Serpasil)FDA Link
12/2019
1SaltsIBA
12/2019
1SodiumIBA
12/2019
1Sodium Oxybate (gamma Hydroxybutyrate)FDA Link
12/2019
1Opioid Receptors (Opioid Receptor)IBA
01/2018
1Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)IBA
01/2018
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2018
1CpCpIBA
01/2018
1Therapeutic UsesIBA
01/2018
1AcidsIBA
11/2017
1AS2717638IBA
11/2017
1geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA
11/2017
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
11/2017
1Pharmaceutical PreparationsIBA
02/2016
1BradykininIBA
06/2015
15-HT1A Serotonin ReceptorIBA
06/2014
1resiniferatoxinIBA
06/2014
1Dinoprostone (PGE2)FDA Link
06/2014
15-HT3 Serotonin Receptors (5 HT3 Receptor)IBA
06/2014
1morpholineIBA
03/2014
1Sodium Channel BlockersIBA
09/2009
1Morphine (MS Contin)FDA LinkGeneric
09/2009
1Mexiletine (Mexitil)FDA LinkGeneric
09/2009
1Anticonvulsants (Antiepileptic Drugs)IBA
09/2009
1Gabapentin (Neurontin)FDA LinkGeneric
12/2008
1EnzymesIBA
02/2003
1matriptaseIBA
02/2003

Therapy/Procedure

3Oral Administration
12/2019 - 06/2012
2Spinal Injections
11/2017 - 06/2014
1Therapeutics
11/2017
1Analgesia
06/2014